Which of the following blood group antigens is known to be associated with a decreased risk of malaria?

A Duffy antigen ✓
B Kell antigen
C Rh antigen
D ABO antigen

Explanation

The Duffy antigen has been linked to a decreased risk of malaria, as the parasite that causes malaria uses this antigen to enter red blood cells.

Mnemonic

Duffy = 'duff' chance of getting malaria

Source

Lancet journal article on malaria and blood group antigens
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: high