Which of the following blood components is responsible for the inactivation of factor Va and factor VIIIa during the coagulation process?

A Protein C ✓
B Protein S
C Antithrombin III
D Plasminogen activator inhibitor-1

Explanation

Protein C, upon activation to activated protein C (APC) by thrombin, plays a critical role in the regulation of blood coagulation by inactivating factor Va and factor VIIIa, thus preventing excessive clot formation.

Source

Hematology: Clinical Principles and Applications
Hematology Hematology: Blood Components Hematology: Blood Components Hard MEDICAL Confidence: high