Which of the following anemias is characterized by an abnormality in the globin chain of hemoglobin?

A Sickle cell anemia
B Thalassemia major ✓
C Glucose-6-phosphate dehydrogenase deficiency
D Hereditary spherocytosis

Explanation

Thalassemia major is a genetic disorder characterized by a defect in the production of the globin chain of hemoglobin.

Source

Wintrobe's Clinical Hematology
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high