Which of the following anemias is characterized by a defect in the production of hemoglobin, resulting in red blood cells that are prone to premature destruction?

A Sideroblastic anemia
B Thalassemia major ✓
C Glucose-6-phosphate dehydrogenase deficiency
D Hereditary spherocytosis

Explanation

Thalassemia major is a severe form of anemia caused by a defect in the production of hemoglobin, leading to red blood cells that are prone to premature destruction.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high