Which of the following anemias is associated with an increased risk of developing osteoporosis due to excessive bone marrow expansion?

A Iron deficiency anemia
B Vitamin B12 deficiency anemia
C Thalassemia major ✓
D Sickle cell anemia

Explanation

Thalassemia major is characterized by severe anemia, which leads to excessive bone marrow expansion to compensate for the lack of erythropoiesis, increasing the risk of developing osteoporosis.

Source

American Journal of Hematology
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high