Which enzyme's overexpression is associated with the development of cancer, particularly in the context of tumor metastasis and angiogenesis?

A Matrix metalloproteinase-2 ✓
B Cathepsin D
C Urokinase-type plasminogen activator
D Tissue inhibitor of metalloproteinase-1

Explanation

Matrix metalloproteinase-2 (MMP-2) is an enzyme that breaks down the extracellular matrix, facilitating tumor cell invasion and metastasis. Its overexpression is associated with the development of various types of cancer.

Source

Nature Reviews Cancer
Enzymes in Disease Cancer Biology Tumor Metastasis and Angiogenesis Medium MEDICAL Confidence: high