Which enzyme's overexpression is associated with an increased risk of developing resistance to chemotherapy in cancer cells?

A Aldehyde dehydrogenase
B Glutathione S-transferase ✓
C Dihydrofolate reductase
D Topoisomerase II alpha

Explanation

Glutathione S-transferase is involved in the detoxification of various chemotherapeutic agents, and its overexpression can lead to increased resistance to chemotherapy.

Source

[DOI: 10.1038/sj.bjc.6600755]
Enzymes in Disease Cancer Biology Chemotherapy Resistance Hard MEDICAL Confidence: medium