Which enzyme's mutation is associated with an increased risk of developing Gaucher's disease, a lysosomal storage disorder characterized by the accumulation of glucocerebroside?

A Glucocerebrosidase ✓
B Hexosaminidase A
C Alpha-Galactosidase A
D Beta-Hexosaminidase B

Explanation

Glucocerebrosidase is the enzyme responsible for breaking down glucocerebroside. Mutations in the gene encoding this enzyme lead to Gaucher's disease, a condition characterized by the accumulation of glucocerebroside in lysosomes.

Source

OMIM Database
Enzymes in Disease Molecular Biology Lysosomal Storage Disorders Medium MEDICAL Confidence: high