Which enzyme's inhibition by certain medications can lead to an increase in homocysteine levels, a risk factor for cardiovascular disease?

A Methionine synthase
B Dihydrofolate reductase ✓
C Cystathionine beta-synthase
D Methylenetetrahydrofolate reductase

Explanation

Inhibition of dihydrofolate reductase by certain medications can lead to an increase in homocysteine levels, as this enzyme is involved in the conversion of homocysteine to methionine.

Source

Pharmacology textbooks
Enzymes in Disease Biochemistry One-Carbon Metabolism Medium MEDICAL Confidence: high