Which enzyme's deficiency is associated with an increased risk of gout and kidney stones?

A Hypoxanthine-guanine phosphoribosyltransferase
B Xanthine oxidase ✓
C Adenosine deaminase
D Glucose-6-phosphatase

Explanation

Xanthine oxidase is involved in the breakdown of purines. Its deficiency can lead to an accumulation of xanthine, which can increase the risk of gout and kidney stones.

Source

_OMIM_
Enzymes in Disease Biochemistry Purine Metabolism Disorders Hard MEDICAL Confidence: high