Which enzyme's abnormal activity is associated with the development of Parkinson's disease, leading to a decrease in dopamine production in the brain?

A Monoamine Oxidase B ✓
B Catechol-O-Methyltransferase
C Dihydropteridine Reductase
D Tyrosine Hydroxylase

Explanation

Monoamine Oxidase B (MAO-B) is an enzyme that breaks down dopamine in the brain. Inhibitors of MAO-B are used in the treatment of Parkinson's disease to increase dopamine levels. Abnormal activity of this enzyme can lead to decreased dopamine production, contributing to the development of Parkinson's disease.

Source

Textbook of Medical Biochemistry
Enzymes in Disease Neurochemistry Neurodegenerative Diseases Hard MEDICAL Confidence: high