Which enzyme's abnormal activity is associated with an increased risk of developing Parkinson's disease, characterized by the formation of Lewy bodies?

A Monoamine oxidase B ✓
B Catechol-O-methyltransferase
C Tyrosine hydroxylase
D Dopamine beta-hydroxylase

Explanation

The abnormal activity of monoamine oxidase B is associated with an increased risk of developing Parkinson's disease, characterized by the formation of Lewy bodies.

Mnemonic

_MOB = Motor Output Blocked → monoamine oxidase B 'blocks' motor output in Parkinson's

Source

Nature Reviews Neuroscience
Enzymes in Disease Neurobiology Neurodegenerative Disorders Medium MEDICAL Confidence: high