Which enzyme is responsible for the conversion of phenylalanine to tyrosine, and what is the consequence of its deficiency?

A Phenylalanine hydroxylase, and its deficiency leads to albinism
B Tyrosinase, and its deficiency leads to phenylketonuria (PKU)
C Phenylalanine hydroxylase, and its deficiency leads to phenylketonuria (PKU) ✓
D Dihydropteridine reductase, and its deficiency leads to hyperphenylalaninemia

Explanation

Phenylalanine hydroxylase is the enzyme responsible for converting phenylalanine to tyrosine. Its deficiency leads to the accumulation of phenylalanine, causing phenylketonuria (PKU), a genetic disorder characterized by intellectual disability and other neurological problems.

Source

OMIM: Phenylketonuria
Enzymes in Disease Biochemistry Amino Acid Metabolism Hard MEDICAL Confidence: high