Which enzyme is involved in the catabolism of homogentisic acid, and what disease is caused by its deficiency?

A Homogentisate 1,2-dioxygenase and alkaptonuria ✓
B Catecholamine dioxygenase and Parkinson's disease
C Tyrosinase and albinism
D Aspartate aminotransferase and liver disease

Explanation

Homogentisate 1,2-dioxygenase is an enzyme involved in the catabolism of homogentisic acid, and its deficiency causes alkaptonuria, a rare genetic disorder characterized by the accumulation of homogentisic acid in the body.

Source

Medical Biochemistry textbook by U. Satyanarayana
Enzymes in Disease Biochemistry Amino Acid Metabolism Disorders Hard MEDICAL Confidence: high