Which enzyme deficiency is associated with the disease tyrosinemia type 1?

A Fumarylacetoacetate hydrolase ✓
B Tyrosine aminotransferase
C Phenylalanine hydroxylase
D Homogentisate 1,2-dioxygenase

Explanation

Tyrosinemia type 1 is caused by a deficiency of the enzyme fumarylacetoacetate hydrolase, which is involved in the breakdown of tyrosine.

Source

Scriver's The Metabolic and Molecular Bases of Inherited Disease
Enzymes in Disease Genetics Inborn Errors of Metabolism Hard MEDICAL Confidence: high