Which coagulation disorder is characterized by a deficiency of plasminogen activator inhibitor-1 (PAI-1)?

A Thrombotic thrombocytopenic purpura (TTP)
B Hemophilia A
C Factor V Leiden deficiency
D Congenital plasminogen activator inhibitor-1 deficiency ✓

Explanation

PAI-1 is a protein that inhibits plasminogen activators, thereby regulating fibrinolysis. A deficiency of PAI-1 can lead to increased fibrinolytic activity and a bleeding tendency.

Source

Williams Hematology, 9th edition
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: medium