What is the term for the abnormal hemoglobin variant that results from a point mutation in the HBB gene, leading to the substitution of glutamic acid with valine at position 6?

A Hemoglobin C
B Hemoglobin S ✓
C Hemoglobin E
D Hemoglobin F

Explanation

The abnormal hemoglobin variant resulting from this specific mutation is known as Hemoglobin S, which is responsible for sickle cell disease.

Source

Robbins and Cotran Pathologic Basis of Disease
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: high