What is the significance of the hemoglobin tetramer's cooperative binding of oxygen?

A It allows for a higher affinity for oxygen at low partial pressures
B It enables the efficient release of oxygen to tissues at high partial pressures ✓
C It facilitates the transport of carbon dioxide from tissues to lungs
D It helps to maintain blood pH homeostasis

Explanation

The cooperative binding of oxygen by the hemoglobin tetramer allows for a sigmoidal oxygen-hemoglobin dissociation curve, which enables the efficient release of oxygen to tissues at high partial pressures.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high