What is the significance of the differences in globin chain composition between adult hemoglobin and fetal hemoglobin in terms of oxygen binding?

A Adult hemoglobin has a higher affinity for oxygen than fetal hemoglobin
B Fetal hemoglobin has a lower affinity for oxygen than adult hemoglobin
C Fetal hemoglobin has a higher affinity for oxygen than adult hemoglobin, allowing for efficient oxygen transfer from mother to fetus ✓
D The globin chain composition does not affect oxygen binding

Explanation

Fetal hemoglobin has a higher affinity for oxygen than adult hemoglobin due to its unique globin chain composition, which allows for efficient oxygen transfer from the mother's bloodstream to the fetus.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high