What is the significance of heparan sulfate proteoglycans in hematopoietic stem cell homing?

A They inhibit the adhesion of hematopoietic stem cells to the bone marrow niche
B They promote the adhesion of hematopoietic stem cells to the bone marrow niche ✓
C They are involved in the regulation of hematopoietic stem cell proliferation
D They are not involved in hematopoietic stem cell homing

Explanation

Heparan sulfate proteoglycans promote the adhesion of hematopoietic stem cells to the bone marrow niche by interacting with chemokines and other molecules, facilitating their homing and retention.

Source

Nature journal
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high