What is the role of von Willebrand factor in the coagulation cascade, particularly in relation to platelet adhesion and aggregation?

A It acts as a cofactor for factor VIII in the intrinsic pathway
B It facilitates platelet adhesion to damaged endothelium and aggregation at the site of injury ✓
C It inhibits the activity of factor Xa in the coagulation cascade
D It enhances fibrinolysis by activating plasminogen

Explanation

Von Willebrand factor plays a critical role in the initiation of hemostasis by facilitating platelet adhesion to damaged endothelium and promoting platelet aggregation at the site of injury.

Source

Hematology textbooks and research articles
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high