What is the role of the ubiquitin-proteasome pathway in regulating hematopoietic stem cell self-renewal and differentiation?

A It promotes self-renewal by degrading pro-differentiation proteins
B It inhibits self-renewal by degrading pro-self-renewal proteins ✓
C It has no role in regulating hematopoietic stem cell self-renewal and differentiation
D It regulates the cell cycle of hematopoietic stem cells

Explanation

The ubiquitin-proteasome pathway plays a crucial role in regulating hematopoietic stem cell self-renewal and differentiation by degrading pro-self-renewal proteins, thereby promoting differentiation.

Source

Recent research studies on hematopoiesis
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high