What is the role of the aryl hydrocarbon receptor in regulating hematopoietic stem cell self-renewal and differentiation?

A It promotes self-renewal and inhibits differentiation
B It inhibits self-renewal and promotes differentiation ✓
C It has no effect on hematopoietic stem cells
D It only regulates the proliferation of mature blood cells

Explanation

The aryl hydrocarbon receptor has been shown to regulate the balance between self-renewal and differentiation of hematopoietic stem cells, with its activation leading to increased differentiation and decreased self-renewal.

Source

Recent research studies on hematopoiesis
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high