What is the role of plasminogen activator inhibitor-1 (PAI-1) in the regulation of fibrinolysis?

A It activates plasminogen to form plasmin
B It inhibits the activation of plasminogen to form plasmin ✓
C It has no role in fibrinolysis
D It converts fibrinogen to fibrin

Explanation

PAI-1 is a protein that inhibits the activation of plasminogen to form plasmin, thereby regulating fibrinolysis and preventing excessive clot breakdown.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high