What is the role of plasminogen activator inhibitor-1 in the regulation of fibrinolysis?

A It activates plasminogen to form plasmin
B It inhibits the activity of tissue plasminogen activator ✓
C It enhances the formation of fibrin from fibrinogen
D It degrades cross-linked fibrin

Explanation

Plasminogen activator inhibitor-1 is a protein that inhibits the activity of tissue plasminogen activator, thereby regulating the fibrinolytic process and preventing excessive clot lysis.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high