What is the role of plasminogen activator inhibitor-1 in the coagulation pathway?

A It inhibits the activation of plasminogen to plasmin ✓
B It activates the conversion of plasminogen to plasmin
C It inhibits the formation of fibrin clots
D It enhances the activity of thrombin

Explanation

Plasminogen activator inhibitor-1 (PAI-1) is a protein that inhibits the activation of plasminogen to plasmin, which is involved in the breakdown of blood clots.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high