What is the role of plasminogen activator inhibitor-1 in the coagulation cascade?

A It activates plasminogen to form plasmin
B It inhibits the activation of plasminogen to form plasmin ✓
C It stabilizes the formation of fibrin clots
D It regulates the synthesis of vitamin K-dependent clotting factors

Explanation

Plasminogen activator inhibitor-1 (PAI-1) is a protein that inhibits the activation of plasminogen to form plasmin, which is responsible for breaking down blood clots.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high