What is the role of Notch signaling in hematopoiesis?

A Promoting differentiation of hematopoietic stem cells into erythrocytes
B Regulating the self-renewal and proliferation of hematopoietic stem cells ✓
C Inhibiting the development of lymphoid progenitor cells
D Enhancing the apoptosis of myeloid progenitor cells

Explanation

Notch signaling plays a crucial role in regulating the self-renewal and proliferation of hematopoietic stem cells, maintaining their undifferentiated state.

Source

Molecular Cell Biology by Lodish et al.
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Medium MEDICAL Confidence: high