What is the role of nitric oxide in regulating hemoglobin's oxygen affinity?

A It increases oxygen affinity by binding to the beta-globin subunit

B It decreases oxygen affinity by binding to the alpha-globin subunit ✓

C It has no effect on oxygen affinity

D It increases oxygen affinity by binding to the heme group

Nitric oxide binds to the alpha-globin subunit, decreasing oxygen affinity and facilitating the release of oxygen to tissues.

Journal of Biological Chemistry

Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: medium

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