What is the role of hypoxia-inducible factor 1 alpha (HIF-1α) in the regulation of hematopoietic stem cell function?

A It promotes the differentiation of hematopoietic stem cells into mature blood cells
B It inhibits the proliferation of hematopoietic stem cells
C It maintains the quiescence of hematopoietic stem cells ✓
D It regulates the migration of hematopoietic stem cells to the bone marrow niche

Explanation

HIF-1α is a transcription factor that plays a crucial role in maintaining the quiescence of hematopoietic stem cells, which is essential for their long-term self-renewal and maintenance.

Source

Nature Reviews Immunology
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high