What is the role of hemoglobin's beta-globin subunit in the regulation of oxygen binding?

A It increases the affinity of hemoglobin for oxygen
B It decreases the affinity of hemoglobin for oxygen
C It has no effect on the affinity of hemoglobin for oxygen
D It regulates the binding of carbon dioxide to hemoglobin
The beta-globin subunit plays a crucial role in regulating oxygen binding to hemoglobin. Mutations in the beta-globin gene can lead to disorders such as beta-thalassemia.
Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high