What is the role of enzyme pyruvate kinase in the progression of cancer?

A It inhibits cell growth by reducing ATP production
B It promotes cell growth by increasing ATP production
C It has no effect on cell growth or ATP production
D It increases glucose uptake in cancer cells ✓

Explanation

Pyruvate kinase is an enzyme that plays a crucial role in glycolysis. In cancer cells, pyruvate kinase is often upregulated, leading to increased glucose uptake and ATP production, which promotes cell growth and proliferation.

Source

Nature Reviews Cancer
Enzymes in Disease Biochemistry Cancer Metabolism Hard MEDICAL Confidence: high