What is the role of 2,3-bisphosphoglycerate in the regulation of hemoglobin's oxygen affinity?

A It increases the affinity of hemoglobin for oxygen
B It decreases the affinity of hemoglobin for oxygen ✓
C It has no effect on the affinity of hemoglobin for oxygen
D It stabilizes the tetrameric structure of hemoglobin

Explanation

2,3-bisphosphoglycerate is an allosteric effector that binds to deoxyhemoglobin, decreasing its affinity for oxygen and facilitating the release of oxygen to tissues.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high