What is the role of 2,3-Bisphosphoglycerate in the regulation of hemoglobin's oxygen binding affinity?

A It increases the oxygen binding affinity of hemoglobin
B It decreases the oxygen binding affinity of hemoglobin ✓
C It has no effect on the oxygen binding affinity of hemoglobin
D It only affects the oxygen binding affinity of fetal hemoglobin

Explanation

2,3-Bisphosphoglycerate is an allosteric effector that binds to hemoglobin and decreases its oxygen binding affinity, allowing for the release of oxygen to tissues.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high