What is the purpose of using a 'two-stage' crossmatching technique in blood banking?

A To detect ABO incompatibility
B To detect non-ABO antibodies
C To reduce the risk of transfusion-related acute lung injury (TRALI)
D To improve the sensitivity of antibody detection
The two-stage crossmatching technique is used to detect non-ABO antibodies, which can cause a hemolytic transfusion reaction.
AABB Technical Manual
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: high