What is the purpose of using a 'major crossmatch' in blood banking?

A To detect the presence of alloantibodies against red blood cell antigens
B To identify the ABO blood group of a patient
C To determine the compatibility of donor red blood cells with the recipient's plasma ✓
D To screen for infectious diseases in donated blood

Explanation

A major crossmatch is used to determine the compatibility of donor red blood cells with the recipient's plasma, which helps to prevent an adverse transfusion reaction.

Source

AABB Technical Manual
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Easy MEDICAL Confidence: high