What is the primary purpose of performing a major crossmatch in blood banking?

A To detect the presence of antibodies against the ABO blood group antigens
B To identify the Rh blood type of the recipient
C To ensure compatibility between the donor's red blood cells and the recipient's plasma ✓
D To determine the presence of bacterial contamination in the blood product

Explanation

A major crossmatch is performed to ensure that the donor's red blood cells are compatible with the recipient's plasma, reducing the risk of an adverse transfusion reaction.

Source

American Association of Blood Banks (AABB) guidelines
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Easy MEDICAL Confidence: high