What is the primary mechanism by which warfarin exerts its anticoagulant effect in patients with coagulation disorders?

A Inhibition of factor II synthesis ✓
B Inhibition of platelet aggregation
C Enhancement of fibrinolysis
D Inhibition of thrombin activation

Explanation

Warfarin works by inhibiting the synthesis of vitamin K-dependent clotting factors, including factor II (prothrombin), which is essential for the coagulation cascade.

Mnemonic

WARfarin = Works Against Romance (factor II inhibition)

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high