What is the primary mechanism by which the kidneys regulate bicarbonate levels in the body?

A Reabsorption of bicarbonate in the proximal convoluted tubule ✓
B Excretion of bicarbonate in the distal convoluted tubule
C Secretion of bicarbonate in the collecting duct
D Reabsorption of bicarbonate in the loop of Henle

Explanation

The kidneys play a crucial role in maintaining acid-base balance by regulating bicarbonate levels. The primary mechanism by which they do this is through the reabsorption of bicarbonate in the proximal convoluted tubule.

Source

Guyton and Hall Textbook of Medical Physiology
Electrolytes and Acid-Base Balance Renal Physiology Bicarbonate Regulation Medium MEDICAL Confidence: high