What is the primary mechanism by which the ABO blood group system influences the outcome of hematopoietic stem cell transplantation?

A Graft-versus-host disease
B Graft rejection due to ABO incompatibility ✓
C Immune response to minor histocompatibility antigens
D Engraftment failure due to ABO mismatch

Explanation

ABO incompatibility can lead to graft rejection, which is a significant concern in hematopoietic stem cell transplantation.

Source

American Journal of Hematology
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high