What is the primary mechanism by which hepcidin regulates iron homeostasis in the body?

A By inhibiting the absorption of iron from the gut
B By stimulating the release of iron from macrophages
C By binding to ferroportin and inducing its internalization ✓
D By increasing the expression of transferrin receptors

Explanation

Hepcidin plays a crucial role in regulating iron homeostasis by binding to ferroportin, the only known iron exporter, and inducing its internalization and degradation, thereby reducing iron export from cells.

Source

National Institute of Diabetes and Digestive and Kidney Diseases
Hematology Hematology: Blood Components Hematology: Blood Components Hard MEDICAL Confidence: high