What is the primary mechanism by which heparin exerts its anticoagulant effect in the treatment of coagulation disorders?

A Inhibition of thrombin formation ✓
B Enhancement of fibrinolysis
C Activation of protein C
D Inhibition of platelet aggregation

Explanation

Heparin primarily works by activating antithrombin III, which then inhibits thrombin and other coagulation factors, thereby preventing clot formation.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high