What is the primary mechanism by which hemoglobin's oxygen-binding affinity is regulated in response to changes in intracellular pH?

A The Bohr effect ✓
B The Haldane effect
C The Henderson-Hasselbalch equation
D The Hill equation

Explanation

The Bohr effect describes how a decrease in pH (increase in acidity) leads to a decrease in hemoglobin's oxygen-binding affinity, facilitating oxygen release to tissues.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high