What is the primary mechanism by which hemoglobin releases oxygen to tissues with high energy demands?

A Increased pH
B Decreased temperature
C Increased CO2 and decreased pH ✓
D Increased oxygen levels

Explanation

Hemoglobin releases oxygen in response to increased CO2 and decreased pH, which occurs in tissues with high energy demands.

Mnemonic

CO2 and acid → 'load' the oxygen off

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high