What is the primary mechanism by which hemoglobin releases oxygen to the tissues?

A Increase in pH
B Decrease in temperature
C Increase in CO2 levels
D Conformational change in hemoglobin structure ✓

Explanation

Hemoglobin releases oxygen to the tissues through a conformational change in its structure, which occurs when it binds to 2,3-BPG or experiences a decrease in pH.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high