What is the primary mechanism by which hematopoietic stem cells maintain their quiescence in the bone marrow niche?

A Cell cycle arrest ✓
B Apoptosis
C Differentiation
D Senescence

Explanation

Hematopoietic stem cells maintain their quiescence in the bone marrow niche primarily through cell cycle arrest, which allows them to remain dormant and preserve their self-renewal capacity.

Source

Nature Reviews Immunology
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high