What is the primary mechanism by which anemia of chronic disease leads to a decrease in erythropoiesis?

A Decreased iron availability due to inflammation
B Increased hepcidin levels leading to iron sequestration ✓
C Direct suppression of erythropoietin production by inflammatory cytokines
D Enhanced apoptosis of erythroid progenitor cells

Explanation

Anemia of chronic disease is characterized by increased hepcidin levels, which lead to iron sequestration and decreased iron availability for erythropoiesis.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high