What is the primary mechanism by which alpha-galactosidase A deficiency leads to Fabry disease?

A Accumulation of globotriaosylceramide in lysosomes ✓
B Inhibition of glycolysis
C Enhanced activity of beta-galactosidase
D Defective transport of glucose across cell membranes

Explanation

Fabry disease is caused by a deficiency of alpha-galactosidase A, leading to the accumulation of globotriaosylceramide in lysosomes, which results in cellular dysfunction.

Source

Scriver's The Metabolic and Molecular Bases of Inherited Disease
Enzymes in Disease Biochemistry Lysosomal Storage Diseases Hard MEDICAL Confidence: high