What is the primary mechanism by which activated protein C exerts its anticoagulant effect in the coagulation pathway?

A Inhibition of factor Xa
B Inhibition of thrombin formation
C Inactivation of factors Va and VIIIa ✓
D Stimulation of plasminogen activator

Explanation

Activated protein C primarily exerts its anticoagulant effect by inactivating factors Va and VIIIa, which are essential for the coagulation cascade.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high