What is the primary function of the enzyme pyruvate kinase in red blood cells, and how does its deficiency lead to a specific type of anemia?

A Pyruvate kinase is involved in the synthesis of hemoglobin, and its deficiency leads to sideroblastic anemia
B Pyruvate kinase is involved in glycolysis, and its deficiency leads to pyruvate kinase deficiency anemia ✓
C Pyruvate kinase is involved in the pentose phosphate pathway, and its deficiency leads to glucose-6-phosphate dehydrogenase deficiency anemia
D Pyruvate kinase is involved in the synthesis of ATP, and its deficiency leads to hereditary spherocytosis

Explanation

Pyruvate kinase is an enzyme involved in glycolysis, and its deficiency leads to a specific type of anemia known as pyruvate kinase deficiency anemia, which is characterized by hemolytic anemia due to impaired energy production in red blood cells.

Source

Hematology textbooks and research articles
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high